Rejection of God

THE HEATHEN ARE LOST BECAUSE OF THEIR REJECTION OF GOD
Romans 1:21-23 (NKJV)   because, although they knew God, they did not glorify Him as God, nor were thankful, but became futile in their thoughts, and their foolish hearts were darkened.  Professing to be wise, they became fools,  and changed the glory of the incorruptible God into an image made like corruptible man--and birds and four-footed animals and creeping things.
How does man reject and suppress the knowledge of God?
Man Has Rejected God Through Irreligion
When man removes God from his thinking he become irreligious. The more he learns, the more confirmed he becomes in his unbelief. The “scientific world view” does not allow any room for God. Man may not know much about God, but the point is that he rejects what he does know.